Pulaski County, Missouri: History
Pulaski County's earliest settlers were the Quapaw, Missouria and Osage Native Americans. After the Lewis and Clark Expedition of the early 19th century, white settlers came to the area, many from Kentucky, Tennessee and the Carolinas; the earliest pioneers appeared to have settled as early as 1818, and the town of Waynesville was designated the county seat by the Missouri Legislature in 1833. Like the county, Waynesville is also named after an American Revolutionary hero, Mad Anthony Wayne.